Detection of Lewy body disease in patients with late‐onset depression, anxiety and psychotic disorder with myocardial meta‐iodobenzylguanidine scintigraphy
Identifieur interne : 000754 ( Main/Exploration ); précédent : 000753; suivant : 000755Detection of Lewy body disease in patients with late‐onset depression, anxiety and psychotic disorder with myocardial meta‐iodobenzylguanidine scintigraphy
Auteurs : Katsuji Kobayashi [Japon] ; Hisashi Sumiya [Japon] ; Hiroyuki Nakano [Japon] ; Noriko Akiyama [Japon] ; Katsumi Urata [Japon] ; Yoshifumi Koshino [Japon]Source :
- International Journal of Geriatric Psychiatry [ 0885-6230 ] ; 2010-01.
English descriptors
- KwdEn :
Abstract
Purpose: Lewy body disease (LBD) is comprised of a spectrum of diseases that includes Parkinson's disease (PD), PD dementia (PDD) and dementia with LBD (DLBD), an array of dementia, and motor symptoms. Low uptake of myocardial meta‐iodobenzylguanidine (MIBG) validates diagnosis of LBD. Psychiatric symptoms sometimes precede atypical Parkinsonian syndromes in LBD. Of 34 patients with low MIBG uptake, late‐onset depressive, anxiety, or psychotic symptoms were analyzed in term of clinical profiles. Method: Thirty‐four patients were classed into three groups according to three main symptoms, 11 patients with visual hallucination (VH), 13 with depression‐anxiety (DA), and 10 with psychosis with cognitive disturbance (PCD). Cutoff values of heart‐to‐mediastinum (HM) ratio of MIBG were set at 1.78 in early phase or 1.68 in late phase. Results: Group VH patients showed a trend toward higher age at onset and occipital lobe hypoperfusion. Group DA patients lacked central and core features of DLBD and five of them showed frontal lobe hypoperfusion. Group PCD patients had the highest frequencies of suggestive symptoms and UPDRS scores and showed temporal lobe hypoperfusion. HM ratio was not associated with clinical profiles of three groups. Cognitive function was more severely disturbed in atypical Parkinsonian syndrome cases at an initial visit. Conclusion: Group VH was considered to DLBD, and Group PCD was regarded as PDD or DLBD with early psychotic presentation. Group DA has a possibility of early depression or anxiety disorder of LBD although it lacked DLBD criteria. Atypical Parkinsonian syndromes are associated with cognitive disturbance irrespective of psychiatric profiles. Copyright © 2009 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/gps.2297
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J. Geriat. Psychiatry</title><idno type="ISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2010-01">2010-01</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="55">55</biblScope><biblScope unit="page" to="65">65</biblScope></imprint><idno type="ISSN">0885-6230</idno></series><idno type="istex">1A21DCE7C19F8B28BFC05D4E6E90501A61F60EF7</idno><idno type="DOI">10.1002/gps.2297</idno><idno type="ArticleID">GPS2297</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-6230</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy body disease</term><term>Parkinson's disease</term><term>anxiety disorder</term><term>depression</term><term>meta‐iodobenzylguanidine</term><term>psychotic disorder</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: Lewy body disease (LBD) is comprised of a spectrum of diseases that includes Parkinson's disease (PD), PD dementia (PDD) and dementia with LBD (DLBD), an array of dementia, and motor symptoms. Low uptake of myocardial meta‐iodobenzylguanidine (MIBG) validates diagnosis of LBD. Psychiatric symptoms sometimes precede atypical Parkinsonian syndromes in LBD. Of 34 patients with low MIBG uptake, late‐onset depressive, anxiety, or psychotic symptoms were analyzed in term of clinical profiles. Method: Thirty‐four patients were classed into three groups according to three main symptoms, 11 patients with visual hallucination (VH), 13 with depression‐anxiety (DA), and 10 with psychosis with cognitive disturbance (PCD). Cutoff values of heart‐to‐mediastinum (HM) ratio of MIBG were set at 1.78 in early phase or 1.68 in late phase. Results: Group VH patients showed a trend toward higher age at onset and occipital lobe hypoperfusion. Group DA patients lacked central and core features of DLBD and five of them showed frontal lobe hypoperfusion. Group PCD patients had the highest frequencies of suggestive symptoms and UPDRS scores and showed temporal lobe hypoperfusion. HM ratio was not associated with clinical profiles of three groups. Cognitive function was more severely disturbed in atypical Parkinsonian syndrome cases at an initial visit. Conclusion: Group VH was considered to DLBD, and Group PCD was regarded as PDD or DLBD with early psychotic presentation. Group DA has a possibility of early depression or anxiety disorder of LBD although it lacked DLBD criteria. Atypical Parkinsonian syndromes are associated with cognitive disturbance irrespective of psychiatric profiles. Copyright © 2009 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Kobayashi, Katsuji" sort="Kobayashi, Katsuji" uniqKey="Kobayashi K" first="Katsuji" last="Kobayashi">Katsuji Kobayashi</name></noRegion><name sortKey="Akiyama, Noriko" sort="Akiyama, Noriko" uniqKey="Akiyama N" first="Noriko" last="Akiyama">Noriko Akiyama</name><name sortKey="Kobayashi, Katsuji" sort="Kobayashi, Katsuji" uniqKey="Kobayashi K" first="Katsuji" last="Kobayashi">Katsuji Kobayashi</name><name sortKey="Koshino, Yoshifumi" sort="Koshino, Yoshifumi" uniqKey="Koshino Y" first="Yoshifumi" last="Koshino">Yoshifumi Koshino</name><name sortKey="Koshino, Yoshifumi" sort="Koshino, Yoshifumi" uniqKey="Koshino Y" first="Yoshifumi" last="Koshino">Yoshifumi Koshino</name><name sortKey="Nakano, Hiroyuki" sort="Nakano, Hiroyuki" uniqKey="Nakano H" first="Hiroyuki" last="Nakano">Hiroyuki Nakano</name><name sortKey="Nakano, Hiroyuki" sort="Nakano, Hiroyuki" uniqKey="Nakano H" first="Hiroyuki" last="Nakano">Hiroyuki Nakano</name><name sortKey="Sumiya, Hisashi" sort="Sumiya, Hisashi" uniqKey="Sumiya H" first="Hisashi" last="Sumiya">Hisashi Sumiya</name><name sortKey="Sumiya, Hisashi" sort="Sumiya, Hisashi" uniqKey="Sumiya H" first="Hisashi" last="Sumiya">Hisashi Sumiya</name><name sortKey="Urata, Katsumi" sort="Urata, Katsumi" uniqKey="Urata K" first="Katsumi" last="Urata">Katsumi Urata</name><name sortKey="Urata, Katsumi" sort="Urata, Katsumi" uniqKey="Urata K" first="Katsumi" last="Urata">Katsumi Urata</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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